Rob Pieters Selected Research

Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)

12/2022	Fludarabine exposure predicts outcome after CD19 CAR T-cell therapy in children and young adults with acute leukemia.
6/2022	STAT5 does not drive steroid resistance in T-cell acute lymphoblastic leukemia despite the activation of BCL2 and BCLXL following glucocorticoid treatment.
4/2022	Dexamethasone-Induced Sarcopenia and Physical Frailty in Children With Acute Lymphoblastic Leukemia: Protocol for a Prospective Cohort Study.
1/2022	Efficacy and toxicity of high-risk therapy of the Dutch Childhood Oncology Group in childhood acute lymphoblastic leukemia.
1/2022	Identification and characterization of relapse-initiating cells in MLL-rearranged infant ALL by single-cell transcriptomics.
12/2021	MAPK-ERK is a central pathway in T-cell acute lymphoblastic leukemia that drives steroid resistance.
11/2021	How much asparaginase is needed for optimal outcome in childhood acute lymphoblastic leukaemia? A systematic review.
6/2021	Irinotecan Induces Disease Remission in Xenograft Mouse Models of Pediatric MLL-Rearranged Acute Lymphoblastic Leukemia.
1/2021	Recurrent NR3C1 Aberrations at First Diagnosis Relate to Steroid Resistance in Pediatric T-Cell Acute Lymphoblastic Leukemia Patients.
1/2021	T-cell Acute Lymphoblastic Leukemia: A Roadmap to Targeted Therapies.

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Rob Pieters Research Topics

Disease

121	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 12/2022 - 01/2002
44	Neoplasms (Cancer) 01/2022 - 04/2002
32	Leukemia 12/2022 - 01/2002
18	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 12/2019 - 09/2005
17	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 06/2022 - 01/2006
13	Hypersensitivity (Allergy) 01/2022 - 01/2011
10	Neuroblastoma 01/2022 - 04/2002
10	Residual Neoplasm 01/2022 - 12/2008
9	Brain Neoplasms (Brain Tumor) 07/2013 - 08/2003
8	Glucocorticoid Receptor Deficiency 06/2015 - 08/2005
7	Osteonecrosis (Kienbock's Disease) 01/2021 - 10/2008
6	Wilms Tumor (Wilm's Tumor) 01/2013 - 03/2006
5	Hodgkin Disease (Hodgkin's Disease) 01/2022 - 08/2006
5	Philadelphia Chromosome 12/2018 - 11/2010
5	Mucositis 08/2007 - 06/2006
4	Thrombosis (Thrombus) 01/2020 - 03/2006
4	Stomatitis 10/2018 - 08/2007
4	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2016 - 01/2012
4	Infections 03/2015 - 04/2012
4	Pathologic Complete Response 04/2011 - 07/2007
4	Ependymoma 12/2008 - 06/2007
3	Hypertriglyceridemia 01/2020 - 02/2012
3	Insulin Resistance 01/2016 - 05/2012
3	Down Syndrome (Down's Syndrome) 07/2015 - 01/2002
3	Carcinoma (Carcinomatosis) 05/2014 - 04/2004
3	Primitive Neuroectodermal Tumors (PNET) 10/2013 - 04/2002
3	Medulloblastoma 12/2008 - 08/2008
2	Pancreatitis 01/2020 - 11/2014
2	Obesity 01/2020 - 01/2012
2	Myeloid Leukemia (Leukemia, Myelocytic) 07/2015 - 04/2013
2	Hematologic Neoplasms (Hematological Malignancy) 10/2013 - 10/2010
2	Diarrhea 07/2013 - 08/2007

Drug/Important Bio-Agent (IBA)

34	Asparaginase (Elspar)FDA Link 01/2022 - 04/2003
24	Pharmaceutical PreparationsIBA 01/2022 - 01/2002
18	Proteins (Proteins, Gene)FDA Link 01/2019 - 08/2003
15	Prednisolone (Predate)FDA LinkGeneric 11/2019 - 08/2004
14	Methotrexate (Mexate)FDA LinkGeneric 12/2019 - 07/2005
12	GlucocorticoidsIBA 06/2022 - 08/2005
12	Dexamethasone (Maxidex)FDA LinkGeneric 04/2022 - 01/2006
8	Messenger RNA (mRNA)IBA 10/2011 - 02/2003
7	SteroidsIBA 06/2022 - 09/2012
7	Vincristine (Oncovin)FDA LinkGeneric 11/2019 - 08/2004
7	Biological ProductsIBA 01/2019 - 05/2007
7	MicroRNAs (MicroRNA)IBA 05/2017 - 10/2010
7	Biomarkers (Surrogate Marker)IBA 12/2016 - 06/2007
6	Prednisone (Sone)FDA LinkGeneric 01/2022 - 12/2007
6	AntibodiesIBA 01/2022 - 01/2011
6	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 01/2021 - 08/2005
5	Transcription Factors (Transcription Factor)IBA 01/2021 - 07/2009
5	Imatinib Mesylate (Gleevec)FDA Link 12/2018 - 09/2012
4	inhibin BIBA 11/2016 - 10/2007
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2006 - 04/2002
3	Cyclophosphamide (Cytoxan)FDA LinkGeneric 12/2022 - 11/2012
3	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2022 - 01/2014
3	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 12/2021 - 12/2016
3	Daunorubicin (Cerubidine)FDA LinkGeneric 01/2021 - 08/2004
3	AsparagineIBA 01/2020 - 12/2008
3	Folic Acid (Vitamin M)FDA LinkGeneric 01/2019 - 07/2005
3	EnzymesIBA 01/2018 - 02/2003
3	multidrug resistance-associated protein 1IBA 05/2014 - 04/2004
3	AnticoagulantsIBA 03/2014 - 08/2008
3	Small Interfering RNA (siRNA)IBA 05/2013 - 05/2008
3	Doxorubicin (Adriamycin)FDA LinkGeneric 06/2009 - 08/2007
3	Cytarabine (Cytosar-U)FDA LinkGeneric 07/2007 - 02/2003
3	LigandsIBA 11/2003 - 04/2002
2	Chimeric Antigen ReceptorsIBA 12/2022 - 01/2022
2	fludarabineIBA 12/2022 - 01/2006
2	Indicators and Reagents (Reagents)IBA 04/2022 - 01/2022
2	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2021 - 03/2014
2	Thymidylate SynthaseIBA 10/2018 - 07/2005
2	pegaspargase (Oncaspar)FDA Link 01/2018 - 04/2011
2	Tyrosine Kinase InhibitorsIBA 01/2018 - 03/2014
2	Immunoglobulins (Immunoglobulin)IBA 01/2018 - 05/2012
2	TensinsIBA 01/2016 - 07/2014
2	nuclear pore complex protein 98IBA 01/2016 - 09/2011
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2016 - 07/2014
2	Hydrocortisone (Cortisol)FDA LinkGeneric 01/2016 - 04/2015
2	Mercaptopurine (6 Mercaptopurine)FDA LinkGeneric 08/2014 - 07/2013
2	Drug CombinationsIBA 10/2013 - 06/2007
2	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 10/2013 - 09/2005
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 05/2013 - 02/2003
2	Anaplastic Lymphoma KinaseIBA 03/2012 - 10/2011
2	Core Binding Factors (Core-Binding Factor)IBA 10/2011 - 03/2011
2	Oncogene Proteins (Oncogene Protein)IBA 05/2011 - 08/2003
2	Anti-Bacterial Agents (Antibiotics)IBA 02/2011 - 05/2007
2	Procarbazine (Matulane)FDA Link 06/2009 - 12/2007
2	Dacarbazine (DIC)FDA LinkGeneric 06/2009 - 12/2007
2	Vinblastine (Vinblastine Sulfate)FDA Link 06/2009 - 12/2007
2	Epirubicin (Ellence)FDA LinkGeneric 06/2009 - 12/2007
2	Bleomycin (Blenoxane)FDA LinkGeneric 06/2009 - 12/2007

Therapy/Procedure

41	Therapeutics 04/2022 - 09/2006
27	Drug Therapy (Chemotherapy) 01/2020 - 08/2004
9	Aftercare (After-Treatment) 11/2016 - 12/2007
7	Stem Cell Transplantation 01/2022 - 09/2012
6	Radiotherapy 03/2016 - 12/2007
6	Combination Drug Therapy (Combination Chemotherapy) 06/2009 - 04/2005
2	Immunotherapy 01/2022 - 11/2005
2	Palliative Care (Palliative Therapy) 01/2017 - 12/2016
2	Hematopoietic Stem Cell Transplantation 11/2010 - 10/2010
2	Drug Tapering 07/2010 - 03/2010